Blue snowflake with the words ICICLE-Gait written below in blue.

A prospective study of gait as a biomarker for cognitive decline in Parkinson’s Disease

Funder: Parkinson’s UK, NIHR and Peggy Coates Bequest

Chief Investigator: Professor Lynn Rochester

Contact: Dr Lisa Alcock, Dr Silvia Del Din

Background & Aims

A black background illustration featuring two human profiles connected by an arrow, with a ball of yarn inside one profile's head and a tangled line inside the other, along with a gear icon at the top connected by arrows. 
ICICLE-GAIT is a sub-study of ICICLE-PD (Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation – Parkinson’s Disease), which aims to better understand the mechanisms determining the transition from Parkinson’s disease (PD) to PD dementia in an incident cohort.
A circular diagram illustrating the cycle of human development, including stages of walking, falling, and recovery, with icons of a person walking, falling, and a head with puzzle pieces, set against a black background. 
The study protocol involved a comprehensive evaluation of gait, balance and cognitive function, falls, and other non-motor features of Parkinson’s Disease.
An illustration of a person walking on a dotted line, with a thought bubble containing three question marks and an arrow pointing towards a brain filled with a tangled line, symbolizing thinking or confusion. 
The principle aim of ICICLE-GAIT is to examine the utility of gait as a surrogate marker of cognitive decline in idiopathic PD.

Objectives

A circular infographic with silhouettes of people, showing a lifespan of 72 months, from 18 to 72 years. 
Recruitment commenced in 2010 and was completed in April 2012 with 121 people with PD participating along with 184 age-matched controls. Participants were reassessed at 18, 36, 54 and 72 month follow-up.

Outcomes

Flowchart illustrating the connection between walking, mental activity, and foot injury, with a person walking in the center, arrows pointing to a brain with tangled lines and a foot with a sharp pain symbol. 
Gait data will be used to predict those at risk for cognitive decline, dementia, postural instability, and future falls.
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