MOTION
Mobility Observation, Translation and Innovation in Neurodegeneration
MOTION Lead: Dr Lisa Alcock
Senior Research Associate
Gait Laboratory Lead, Clinical Ageing Research Unit
Email: lisa.alcock@newcastle.ac.uk
Dr Lisa Alcock is a biomechanist specialising in mobility impairment in ageing and neurodegeneration using instrumented techniques.
Lisa leads the Mobility Observation, Translation and Innovation in Neurodegeneration (MOTION) team, which aims to characterise signatures of mobility impairment in ageing and neurodegeneration to understand the impact on daily function and relevance to clinical events such as falls. Her program of research aims to use insights from clinical and real-world environments to inform the development of interventions designed to create safer environments and optimise locomotor safety.
She also leads a Gait laboratory integrated within an NIHR clinical research facility (Clinical Ageing Research Unit). We see over 250 patients every year for clinical research and the team has significant expertise in the design of novel protocols, validation of new technologies, delivery of complex clinical trials and implementing bespoke analytics.
MOTION Team
Postdoctoral Research Associates
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Dr Metin Bicer
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Dr Marta Mirando
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Dr Aron Syversen
PhD & MD Students
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Miss Adenike Adesanya
Jain Foundation PhD Student
PhD Title: Characterising gait impairment in dysferlinopathy: disease progression and therapeutic response.
Supervisors: Dr Lisa Alcock, Dr Karen Suetterlin, Professor Volker Straub
Email: a.adesanya2@newcastle.ac.uk
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Emily Chruscikowski
Mental Health Mission/Newcastle NIHR BRC PhD student
PhD title: Movement as a biomarker in bipolar disorder
Supervisors: Prof Hamish McAllister-Williams, Dr Stuart Watson, Dr Lisa Alcock, Dr Silvia Del Din
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Miss Emma Packer
NUAcT PhD Student
PhD Title: Leveraging digital health technology and insights from people with Parkinson’s to explore medication effect on real-world mobility
Supervisors: Dr Silvia Del Din, Dr Lisa Alcock, Prof Alison Yarnall, Prof Jaume Bacardit
Email: e.packer@newcastle.ac.uk
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Ms Naveed E Saba
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Mr Mohammadreza Sedghi
NIHR Newcastle BRC PhD Student
PhD Title: Discovering digital biomarkers of activity and sleep in ageing and diverse neurological populations
Supervisors: Dr Rachael Lawson, Dr Lisa Alock, Dr Silvia Del Din, Prof John-Paul Taylor
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Miss Claire Wilkinson
NIHR Newcastle PhD Student
PhD Title: Characterizing and validating turn strategies in the real-world in people with Parkinson’s disease
Supervisors: Dr Lisa Alcock, Dr Silvia Del Din, Prof Lynn Rochester, Dr Kirsty Alcock
Email: c.wilkinson8@necastle.ac.uk
MOTION Studies
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MRC Multimorbidity Project
Real-world gait in people with multiple long-term conditions
Funder: MRCPrincipal Investigator: Professor Ioannis Vogiatzis
Co-Investigators: Dr Silvia Del Din, Dr Lisa Alcock
Team members: Dr Kirsty Scott
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SUSTAIN Mobilise-D
Funder: EU-IMI & EPFIA
Principle Investigator: Silvia Del Din
Co-Investigators: Prof Lynn Rochester, Dr Lisa Alcock
Collaborating Institution: University College Dublin
Team members: Dr Metin Bicer, Dr Lou Sutcliffe
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EJS-ACT PD
The Edmond J. Safra Accelerating Clinical Trials for Parkinson’s Disease: Digital Measures Study
Funder: Efficacy and Mechanism Evaluation (EME) Programme, an MRC and NIHR partnership, Cure Parkinson’s, The Michael J Fox Foundation, Parkinson’s UK, The John Black Charitable Foundation, The Gatsby Charitable Foundation and Van Andel Institute
Chief investigator: Prof Camille Carroll
Co-Investigators: Prof Alison Yarnall, Dr Silvia Del Din, Dr Lisa Alcock
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ActivNap
Discovering digital biomarkers of activity and sleep in ageing and diverse neurological populations
Funder: NIHR Newcastle Biomedical Research Centre (BRC)
Principle Investigator: Dr Rachael Lawson
Co-Investigators: Dr Lisa Alcock, Dr Siliva Del Din
Team members: Mohammadreza Sedghi
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DynaMo-PD
Developing a dynamic FDG-PET/MR imaging methodology to stduy gait in Parkinson's
Funder: Parkinson’s UK
Principle Investigator: Prof Lynn
Co-Investigators: Dr Lisa Alcock
Team members: Phil Brown
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POLG
Clinical trial readiness for POLG-related mitochondrial disease and ataxia: a prospective, longitudinal study identifying sensitive and ecologically valid biomarkers (C4TR-POLG)
Funder: The POLG Foundation
Principle Investigator: Dr Yi Shiau Ng
Co-Investigator: Dr Lisa Alcock
Team members: Dr Marta Mirando
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COS-PrePARED
COS-PREPARED: Clinical Outcome Study in PRe- and Early-symptomatic PAtients with REcessive Dysferlinopathy
Funder: Jain Foundation
Co-Investigators: Dr Lisa Alcock
Team members: Adenike Adesanya
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ICICLE-Gait
A prospective study of gait as a biomarker for cognitive decline in Parkinson’s Disease
Funder: Parkinson’s UK, NIHR and Peggy Coates Bequest
Principle Investigator: Professor Lynn Rochester
Team members: Dr Lisa Alcock, Dr Silvia Del Din
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AFAF
Friedreich ataxia: balance and gait study. A longitudinal laboratory and real-world study of gait and balance in people with Friedreich ataxia
Funder: The French Friedreich’s Ataxia Association (AFAF)
Principle Investigator: Dr Yi Shiau Ng
Co-Investigator: Dr Lisa Alcock
Team members: Dr Marta Mirando
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COS II & COS II extension
An International Clinical Outcome Study of Dysferlinopathy
Funder: Jain Foundation
Principle Investigator: Dr Yi Shiau Ng
Co-Investigators: Dr Lisa Alcock
Team members: Adenike Adesanya
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MFM & DM
Integrative analysis of clinical data and biopsy profiles in Distal and Myofilbrillar Myopathies in the UK
Funder: Muscular Dustrophy UK
Principle Investigator: Prof Giorgio Tasca
Co-Investigators: Dr Lisa Alcock
Team members: Ariele Barreto Haagsma
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PPMI
Parkinson's Progression Markers Initiative
Funder: The Michael J Fox Foundation
Principle Investigator: Prof Anat Mirelman
Co-Investigators: Prof Nicola Pavese
Team members: Dr Lisa Alcock, Heather Hunter, Philip Brown, Dr Ellen Lirani-Silva
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CREED
The Cholinergic ResponsE in Early lewy body Disease
Funder: Lewy Body Society
Principle Investigator: Prof John-Paul Taylor
Co-Investigators: Prof Alison Yarnall
Team members: Dr Lisa Alcock, Dr Aron Syversen, Mohammadreza Sedghi
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OACS-3
Obeticholic acid for the Amelioration of Cognitive Symptoms trial - 3
Funder: Intercept PharmaceuticalsPrincipal Investigator: Alison Yarnall
Team members: Kathryn Walker, Dr Lisa Alcock
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Mobilise-D
Funder: EU-IMI & EPFIA
Principle Investigator: Prof Lynn Rochester
Co-Investigators: Prof Alison Yarnall, Dr Silvia Del Din
Team members: Phil Brown, Dr Lisa Alcock, Heather Hunter, Dr Cam Kirk
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A Mobilise-D Extension study
Funder: Michael J Fox Foundation
Chief Investigator: Prof Alison Yarnall
Co-Investigators: Prof Lynn Rochester, Dr Silvia Del Din
Team members: Dr Lisa Alcock, Dr Hannah Blackburn, Dr Ellen Lirani-Silva, Dr Cameron Kirk, Dr Patrick Tait, Philip Brown, Heather Hunter, Isabel Neatrour